Dear Dr Raine                     [See previous correspondence]

It is now almost two months since I came to see you. I wonder whether there has been any progress?

I made a small error when I gave you the original wording by Professor Malt from Norway as regards a possible warning for SSRIs. Malt's original wording was as follows:

"One patient on sertraline committed suicide, and three others reported increasing suicidal ideation which prompted premature stop of the treatment, in contrast to just one case on mianserin and none on placebo. Since the introduction of the tricyclic antidepressants, it has been known by clinicians that TCA could increase suicidality in the first week. For this reason a close supervision of depressed patients given TCA was recommended"

I made another error when asked whether the 400mg Sertraline dose used in the healthy volunteer study by Saletu et al (which I left you a copy of was outside the normal clinical dose range. I suggested that it was but of course it is not.

Many months ago I asked for a copy of material on the SSRI Core Safety Exercise. Is there any sign of this coming my way?

Yours sincerely,

David Healy MD FRCPsych

Director, North Wales Department of Psychological Medicine

Uned Hergest, Ysbyty Gwynedd, Bangor, Gwynedd LL27 2PW

Ffôn: (01248) 384452 Ffacs: (01248) 371397

Hergest Unit, Gwynedd Hospital, Bangor, Gwynedd LL27 2PW

Tel: (01248) 384452 Fax: (01248) 311397

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